To investigate the relationship between corneal biomechanical properties and corneal endothelial morphology in a healthy Saudi adult population, highlighting its significance in clinical practice.
Key Findings:
Males exhibited slightly lower CH, CRF, and endothelial indices, but differences were not significant.
IOPg was significantly higher in hyperopes compared to myopes (p = 0.014).
CCT correlated moderately with CH (r = 0.40, p < 0.0001), CRF (r = 0.53, p < 0.0001), and IOPg (r = 0.50, p < 0.0001).
Endothelial cell number negatively associated with IOPg (r = -0.23, p = 0.011) and IOPcc (r = -0.21, p = 0.021).
CCT emerged as the strongest predictor of ORA outcomes.
Interpretation:
Corneal biomechanics in healthy adults are primarily influenced by central corneal thickness, with endothelial morphology having a secondary effect on biomechanical responses, which is crucial for clinical assessments.
Limitations:
Cross-sectional design limits causal inferences.
Findings may not be generalizable beyond the Saudi population.
Potential biases in participant selection may affect the results.
Conclusion:
The study provides foundational normative data relevant for refractive surgery, glaucoma assessment, and regional screening practices, emphasizing the need for further research in diverse populations.
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