Nafamostat mesilate for anticoagulation in pediatric trauma patients undergoing extracorporeal membrane oxygenation: a two-center observational study in Northwest China - Summary - MDSpire

Nafamostat mesilate for anticoagulation in pediatric trauma patients undergoing extracorporeal membrane oxygenation: a two-center observational study in Northwest China

  • By

  • Weikai Wang

  • Zhe Lv

  • Haitong Wu

  • Hua Zhang

  • Zhen Chen

  • Yong Zhou

  • Zhangyan Guo

  • Jingmei Li

  • Le Ma

  • Dan Yao

  • Ying Wang

  • Ru Lin

  • Yajun Niu

  • Yuhao Ma

  • Xinxin Yan

  • Shan Jia

  • Taining Zhang

  • Yufei Wang

  • Yanqiang Du

  • Yi Wang

  • July 14, 2026

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Objective:

To evaluate the comparative efficacy of regional anticoagulation using nafamostat mesilate vs. systemic anticoagulation with unfractionated heparin in pediatric patients with trauma undergoing ECMO support.

Approach:
  • Outcome Measures: Clinical outcomes evaluated included transfusion requirements, use of coagulation-related agents, incidence of complications, and successful removal.
Key Findings:
  • No significant differences in blood cell classification and coagulation parameters at admission between groups.
  • The UFH group had a higher rate of new-onset active bleeding and circuit thrombosis compared to the nafamostat mesilate group (P < 0.05).
  • Mandatory anticoagulant discontinuation was significantly higher in the UFH group due to increased active bleeding.
Interpretation:

Limitations:
  • Small sample size of 40 patients.
  • Single-center and multi-center data may vary in generalizability.
Conclusion:

Original Source(s)

Nafamostat mesilate for anticoagulation in pediatric trauma patients undergoing extracorporeal membrane oxygenation: a two-center observational study in Northwest China

  • by Weikai Wang, Zhe Lv, Haitong Wu, Hua Zhang, Zhen Chen, Yong Zhou, Zhangyan Guo, Jingmei Li, Le Ma, Dan Yao, Ying Wang, Ru Lin, Yajun Niu, Yuhao Ma, Xinxin Yan, Shan Jia, Taining Zhang, Yufei Wang, Yanqiang Du, Yi Wang

  • July 14, 2026

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