Objective:

To evaluate the impact of log-SDR on clinical outcomes in heart failure patients with different ejection fractions, specifically assessing its prognostic value.

Approach:

• Study Population: Retrospective analysis of 1,221 medical records from patients diagnosed with acute exacerbations of chronic heart failure (AECHF) at the First Affiliated Hospital of Kunming Medical University.
• Data Collection: Collected demographic information, medical history, clinical data, and laboratory parameters from electronic medical records, focusing on serum sodium and D-dimer levels.
• Statistical Analysis: Used Kaplan–Meier curves for survival analysis and Cox regression models to identify predictors of all-cause mortality.

Key Findings:

• Log-SDR was calculated as serum sodium divided by log-transformed D-dimer.
• Patients were stratified into low and high log-SDR groups based on an optimal cut-off value of 47.90.
• The study included 1,008 patients after applying exclusion criteria.

Interpretation:

The log-SDR may serve as a prognostic marker in chronic heart failure, reflecting the interplay between sodium levels and coagulation status.

Limitations:

• Retrospective design may introduce bias.
• Exclusion of patients with certain comorbidities limits generalizability.

Conclusion:

The study indicates that further research is needed to determine the prognostic utility of log-SDR in assessing mortality risk in chronic heart failure patients.