A comprehensive review of guidelines and consensus recommendations for managing women with multiple sclerosis during pre-pregnancy, pregnancy, and the postpartum phase - Summary - MDSpire
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A comprehensive review of guidelines and consensus recommendations for managing women with multiple sclerosis during pre-pregnancy, pregnancy, and the postpartum phase

  • By

  • Elaheh Mansouri Ghezelhesari

  • Malika Vaez Tehrani

  • Mohammadali Nahayati

  • Hosein Ebrahimipour

  • Abbas Heydari

  • Talat Khadivzadeh

  • February 14, 2026

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Objective:

To compile and evaluate existing clinical recommendations related to the care of women with multiple sclerosis (MS) before pregnancy, during pregnancy, and postpartum, emphasizing the importance of addressing their unique needs.

Key Findings:
  • Ten articles met the inclusion criteria for the systematic review.
  • Guidelines specifically addressing the management of women with MS during pregnancy and postpartum are incomplete and scattered, which may lead to inadequate care.
  • Quality assessment indicated varying levels of rigor and clarity among the reviewed guidelines.
Interpretation:

There is a critical need for comprehensive, high-quality guidelines tailored to the unique needs of women with MS during reproductive phases, including specific recommendations on treatment and support.

Limitations:
  • Limited number of guidelines specifically addressing the reproductive health of women with MS, which may affect patient care.
  • Potential bias in guideline selection and quality assessment due to subjective interpretation.
Conclusion:

Improving and consolidating clinical guidelines for managing women with MS during pre-pregnancy, pregnancy, and postpartum is essential for better healthcare outcomes and addressing the identified gaps.

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