Short-term efficacy and safety of percutaneous ultrasound-guided pseudomonas aeruginosa-mannose sensitive hemagglutinin injection in postoperative chyle fistula: a cohort study - Summary - MDSpire
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Short-term efficacy and safety of percutaneous ultrasound-guided pseudomonas aeruginosa-mannose sensitive hemagglutinin injection in postoperative chyle fistula: a cohort study
To assess the short-term effectiveness and safety of percutaneous ultrasound-guided PA-MSHA injection in patients with postoperative chyle fistula following total thyroidectomy with neck dissection.
Key Findings:
PA-MSHA therapy significantly reduced length of hospital stay compared to conservative management (7.57 ± 1.49 vs. 8.86 ± 0.38 days).
Marked decrease in chyle output within 24–48 hours post-PA-MSHA administration.
No surgical re-interventions were required for any patient.
Daily evaluations showed a reduction in drainage volume, but secondary endpoint results need to be highlighted.
Interpretation:
Ultrasound-guided PA-MSHA injection may serve as an effective adjunct to conservative management for postoperative chyle fistula, particularly in reducing hospital stay, but further prospective studies are essential to validate these findings and optimize clinical application.
Limitations:
Retrospective design may introduce bias affecting the reliability of the findings.
Limited sample size and single-center study may affect generalizability.
Conclusion:
PA-MSHA injection shows promise in managing postoperative chyle fistula, warranting further prospective studies to validate findings and optimize clinical application.
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