Submandibular gland preservation versus removal during neck dissection in oral squamous cell carcinoma: a systematic review and meta-analysis - Summary - MDSpire
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Submandibular gland preservation versus removal during neck dissection in oral squamous cell carcinoma: a systematic review and meta-analysis
To assess whether submandibular gland (SMG) preservation compromises oncologic outcomes or improves functional outcomes, particularly xerostomia, in patients with oral squamous cell carcinoma (OSCC).
Key Findings:
Eight studies with 1,220 patients were included.
SMG preservation did not increase locoregional recurrence (RR 1.05, p = 0.81).
No significant effect on disease-specific survival (RR 0.86, p = 0.69) or overall survival (RR 0.80, p = 0.57) compared to gland resection.
Xerostomia outcomes were variably reported; some studies suggested a trend toward reduced postoperative dry mouth with SMG preservation, though findings were inconsistent.
Interpretation:
SMG preservation during neck dissection appears not to compromise oncologic outcomes in selected cases, but the impact on xerostomia remains inconclusive due to study heterogeneity, highlighting the need for careful patient selection.
Limitations:
Low-certainty evidence.
Inconsistencies in xerostomia assessment methods and patient cohorts across studies.
Potential biases in the included studies that may affect the reliability of the findings.
Conclusion:
SMG preservation may be safe in terms of oncologic outcomes, but further research is needed to clarify its impact on xerostomia and to address the identified gaps in the current literature.
