Impact of center volume on outcomes in allogeneic hematopoietic cell transplantation for children - Summary - MDSpire

Impact of center volume on outcomes in allogeneic hematopoietic cell transplantation for children

  • By

  • Motohiro Kato

  • Hideki Nakashone

  • Keitaro Matsuo

  • Yuri Ito

  • Atsumi Yanagisawa

  • Marie Ohbiki

  • Ken Tabuchi

  • Tatsuo Ichinohe

  • Yoshiko Hashii

  • Junya Kanda

  • Hideki Goto

  • Koji Kato

  • Makoto Yoshimitsu

  • Atsushi Sato

  • Moeko Hino

  • Kimikazu Matsumoto

  • Kimikazu Yakushijin

  • Yoshiko Atsuta

  • Takahiro Fukuda

  • April 10, 2025

  • 0 min

Share

Objective:

To assess the center effect on outcomes, specifically overall survival and other relevant clinical outcomes, in pediatric allogeneic hematopoietic cell transplantation (HCT) and provide insights for improving survival rates.

Key Findings:
  • The study included 6966 patients across 123 centers.
  • Overall 5-year OS was 67.4%, with no significant differences among center volume categories (p = 0.85), indicating that center volume may not be a critical factor in pediatric HCT outcomes.
  • Higher volume centers (C3 and C4) had a greater proportion of non-malignant diseases.
Interpretation:

Despite the center volume effect being documented in adult studies, this analysis found no significant differences in outcomes for pediatric HCT based on center volume, suggesting that other factors may be more influential in determining patient outcomes.

Limitations:
  • The study may not account for all variables influencing outcomes, such as specific patient characteristics and treatment protocols, which could skew results.
  • Findings may not be generalizable to all pediatric transplant populations due to the specific focus on Japanese centers, limiting broader applicability.
Conclusion:

Center volume does not appear to significantly impact overall survival in pediatric allogeneic HCT, suggesting that factors beyond volume may play a crucial role in patient outcomes.

Original Source(s)

Impact of center volume on outcomes in allogeneic hematopoietic cell transplantation for children

  • by Motohiro Kato, Hideki Nakashone, Keitaro Matsuo, Yuri Ito, Atsumi Yanagisawa, Marie Ohbiki, Ken Tabuchi, Tatsuo Ichinohe, Yoshiko Hashii, Junya Kanda, Hideki Goto, Koji Kato, Makoto Yoshimitsu, Atsushi Sato, Moeko Hino, Kimikazu Matsumoto, Kimikazu Yakushijin, Yoshiko Atsuta, Takahiro Fukuda

  • April 10, 2025

Related Content

Understanding the Role of Regulatory T Cells in the Immune Microenvironment of Multiple Myeloma and Its Clinical Implications

Tumor-localized CD40 agonism with MP0317, a FAP x CD40 DARPin, reprograms the tumor microenvironment in patients with advanced solid tumors: an open-label, nonrandomized, dose-escalation phase 1 study

This Week’s CGT News: Novo’s Parkinson’s Pivot

Novo Nordisk’s Parkinson’s cell therapy finds a new home at Cellular Intelligence, while base editing, prime editing, and large-insertion genome writing push forward

  • May 18, 2026

  • 7 min