Impact of reperfusion on thrombectomy outcomes in patients with pre-stroke disability - Summary - MDSpire

Impact of reperfusion on thrombectomy outcomes in patients with pre-stroke disability

  • By

  • Sávio Batista

  • Jaydevsinh N. Dolia

  • Jonathan Grossberg

  • Raul Nogueira

  • Santiago Ortega-Gutierrez

  • Sunil Sheth

  • Alex Alqudah

  • Theja Yelam

  • Pedro Nascimento Martins

  • Alhamza R. Al-Bayati

  • Mohamed F. Doheim

  • Lucas Rios Rocha

  • Jorge Cespedes

  • Leonardo Cruz-Criollo

  • Anderson Brito

  • Ngoc Mai Le

  • Hussain M Azeem

  • Joseph N Samaha

  • Diogo C. Haussen

  • July 1, 2026

  • 0 min

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Objective:

To evaluate the impact of reperfusion success on clinical outcomes in patients with pre-stroke disability undergoing mechanical thrombectomy.

Approach:
  • Study Design: Retrospective multicenter cohort study analyzing patients undergoing mechanical thrombectomy for anterior circulation large-vessel occlusion stroke.
  • Participants: 4,840 patients were analyzed, with 1,457 (30.1%) having pre-stroke disability (mRS 1–4).
  • Primary Analysis: Evaluated the impact of successful reperfusion on 90-day mRS shift using ordinal logistic regression adjusted for age, NIHSS, ASPECTS, and occlusion site.
  • Secondary Analyses: Assessed discharge mRS, first-pass effect (FPE), and the effect of disability etiology on outcomes.
Key Findings:
  • Successful reperfusion was associated with improved 90-day mRS for patients with baseline mRS 0–3.
  • Similar benefits were observed for patients with baseline mRS 4, though not statistically significant.
  • Successful reperfusion correlated with lower discharge mRS across all baseline strata.
  • FPE provided consistent clinical benefits regardless of pre-stroke disability level.
  • Outcomes were similar between patients with neurological and non-neurological sources of disability.
Interpretation:

Successful reperfusion is linked to improved functional outcomes across a range of pre-stroke disability levels, with no significant modification of treatment benefits based on disability etiology.

Limitations:
  • Retrospective design may introduce selection bias.
  • Variation in selection practices across centers could affect generalizability.
Conclusion:

These findings suggest that mechanical thrombectomy may be beneficial for appropriately selected patients with pre-existing disability, warranting further studies.

Original Source(s)

Impact of reperfusion on thrombectomy outcomes in patients with pre-stroke disability

  • by Sávio Batista, Jaydevsinh N. Dolia, Jonathan Grossberg, Raul Nogueira, Santiago Ortega-Gutierrez, Sunil Sheth, Alex Alqudah, Theja Yelam, Pedro Nascimento Martins, Alhamza R. Al-Bayati, Mohamed F. Doheim, Lucas Rios Rocha, Jorge Cespedes, Leonardo Cruz-Criollo, Anderson Brito, Ngoc Mai Le, Hussain M Azeem, Joseph N Samaha, Diogo C. Haussen

  • July 1, 2026

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