Case Report: Asymmetric recovery unmasking watershed infarction in a patient with ICU-acquired weakness - Summary - MDSpire

Case Report: Asymmetric recovery unmasking watershed infarction in a patient with ICU-acquired weakness

  • By

  • Bingqing Zhao

  • Meng Yu

  • Peining Zhou

  • Fan Li

  • Junfang Huang

  • Jing Ma

  • Zhaoxia Wang

  • June 24, 2026

  • 0 min

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Objective:

To present a case of a patient with ICU-acquired weakness (ICUAW) who exhibited atypical asymmetric recovery patterns due to underlying neurological complications.

Approach:
  • Case Presentation: A 59-year-old female with severe pneumonia and septic shock developed profound muscle weakness after acute respiratory failure. Initial diagnosis was ICUAW, but subsequent imaging revealed watershed infarctions.
  • Diagnostic Process: The diagnostic approach included ruling out drug-induced and metabolic factors, systemic comorbidities, and acute ICU-acquired neuromuscular complications through various tests and imaging.
  • Rehabilitation Strategy: A tailored rehabilitation strategy focusing on mitochondrial metabolism and active physical therapy was implemented, leading to significant functional improvement.
Key Findings:
  • The patient exhibited distinct asymmetrical motor recovery with persistent left-sided deficits.
  • Cranial MRI revealed fresh watershed infarctions in the right hemisphere.
  • Full recovery was reported at a 2-year follow-up after a multimodal rehabilitation approach.
Interpretation:

The case illustrates that the weaning process can reveal latent cerebrovascular issues in critically ill patients, necessitating a high index of suspicion for asymmetric recovery patterns in ICUAW.

Limitations:
  • The case is a single patient report, limiting generalizability.
  • Potential confounding factors in the patient's complex medical history may complicate the interpretation of findings.
Conclusion:

Clinicians should maintain a high index of suspicion for asymmetric recovery patterns in ICUAW and consider a multimodal approach for accurate diagnosis and management.

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