Long-term efficacy of neural circuit blockade for treating blepharospasm: a retrospective case series study - Summary - MDSpire

Long-term efficacy of neural circuit blockade for treating blepharospasm: a retrospective case series study

  • By

  • Gang Liu

  • Qiangying Guo

  • Jie Xiang

  • Zhen Xu

  • Suying Chen

  • Yanling Xue

  • Zhitao Liu

  • Huixia Jin

  • Shangyi Yu

  • Ting Jiao

  • Xia Chen

  • Zhenzhen Liu

  • Xiangying Xi

  • Yanhong Li

  • Lili Shang

  • Jiao Du

  • Xianzhong Liu

  • Shihui Wei

  • June 24, 2026

  • 0 min

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Objective:

To analyze the long-term efficacy of neural circuit blockade (NCB) for blepharospasm.

Approach:
  • Study Design: A retrospective analysis of 570 patients who underwent NCB treatment, with a median postoperative follow-up of 51 months.
  • Evaluation Methods: Therapeutic efficacy was evaluated using the Shorr blepharospasm grading scale, Burke–Fahn–Marsden Dystonia Rating Scale (BFMDRS-M), and Blepharospasm Disability Index (BSDI).
Key Findings:
  • Preoperatively, 97.9% of patients were grade 4 on the Shorr grading scale; postoperatively, 87.5% achieved complete remission (grade 0).
  • Significant differences in BFMDRS-M scores pre- and postoperatively were observed across various categories.
  • BSDI scores also showed significant improvement postoperatively.
  • NCB was effective in alleviating blepharospasm without causing severe complications.
Interpretation:

NCB effectively alleviates blepharospasm and addresses the lack of a definitive treatment.

Limitations:
  • Loss to follow-up rate was 13.37%, which may affect the representativeness of the results.
  • The study was conducted at a single center, which may limit generalizability.
Conclusion:

NCB can safely and effectively alleviate blepharospasm, improve quality of life, and demonstrate stable long-term efficacy.

Original Source(s)

Long-term efficacy of neural circuit blockade for treating blepharospasm: a retrospective case series study

  • by Gang Liu, Qiangying Guo, Jie Xiang, Zhen Xu, Suying Chen, Yanling Xue, Zhitao Liu, Huixia Jin, Shangyi Yu, Ting Jiao, Xia Chen, Zhenzhen Liu, Xiangying Xi, Yanhong Li, Lili Shang, Jiao Du, Xianzhong Liu, Shihui Wei

  • June 24, 2026

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