To evaluate clinical outcomes following resting full-cycle ratio (RFR) assessment and investigate the association between RFR values > 0.89 and cardiovascular events.
Approach:
Patient Population: Included 773 patients with angiographically intermediate coronary artery disease who underwent RFR assessment leading to deferred revascularization.
Resting Full-Cycle Ratio Measurement: RFR was defined as the lowest Pd/Pa recorded over at least five consecutive cardiac cycles, with a cutoff of 0.89 indicating myocardial ischemia.
Study Endpoints: Primary endpoint was the 2-year incidence of major adverse cardiac events (MACE), with secondary endpoints including all-cause death and vessel-oriented composite outcomes (VOCO).
Key Findings:
RFR assessment was performed on 1012 lesions, with a focus on deferred revascularization.
Interpretation:
The study provides insights into the long-term outcomes of patients with deferred revascularization based on RFR values.
Limitations:
Real-world data validating RFR measurements remain limited and primarily derived from small patient cohorts.
No FFR measurements were included in this cohort for comparison.
Conclusion:
The findings contribute to understanding the clinical utility of RFR in managing coronary artery disease.
