To evaluate clinical outcomes following resting full-cycle ratio (RFR) assessment and investigate the association between RFR values > 0.89 and cardiovascular events.
Approach:
Patient Population: Included 773 patients with angiographically intermediate coronary artery disease who underwent RFR assessment leading to deferred revascularization.
Resting Full-Cycle Ratio Measurement: RFR was defined as the lowest Pd/Pa recorded over at least five consecutive cardiac cycles, with a cutoff of 0.89 indicating myocardial ischemia.
Study Endpoints: Primary endpoint was the 2-year incidence of major adverse cardiac events (MACE), with secondary endpoints including all-cause death and vessel-oriented composite outcomes (VOCO).
Key Findings:
RFR assessment was performed on 1012 lesions, with a focus on deferred revascularization.
Interpretation:
The study provides insights into the long-term outcomes of patients with deferred revascularization based on RFR values.
Limitations:
Real-world data validating RFR measurements remain limited and primarily derived from small patient cohorts.
No FFR measurements were included in this cohort for comparison.
Conclusion:
The findings contribute to understanding the clinical utility of RFR in managing coronary artery disease.
For many people, cardiovascular disease develops silently. It can remain undetected for years, overshadowed by an active lifestyle and an apparent lack of symptoms.
