To compare the diagnostic performance of 18F-FDG PET-CT and SPECT whole-body bone imaging for detecting bone metastases in patients with colorectal cancer.
Key Findings:
Add a note that a total of 533 abnormal lesions were detected across both modalities.
Interpretation:
18F-FDG PET-CT demonstrated significantly higher sensitivity, specificity, and diagnostic accuracy than SPECT for detecting bone metastases from colorectal cancer.
Limitations:
Retrospective design may introduce bias.
Relatively limited sample size.
No pathological biopsy of bone lesions was performed.
Conclusion:
PET-CT may provide superior diagnostic value for predominantly osteolytic bone metastases in colorectal cancer, while SPECT remains an important first-line screening modality.
