Association of the serum uric acid to high-density lipoprotein cholesterol ratio with in-hospital mortality in patients with acute kidney injury: a retrospective cohort study - Summary - MDSpire
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Association of the serum uric acid to high-density lipoprotein cholesterol ratio with in-hospital mortality in patients with acute kidney injury: a retrospective cohort study
To evaluate the association between the uric acid to HDL cholesterol ratio (UHR) and in-hospital mortality among patients with acute kidney injury (AKI).
Approach:
Key Findings:
The study enrolled 435 survivors and 65 non-survivors.
Non-survivors were older and had a higher prevalence of hypertension and diabetes.
Higher serum creatinine, blood urea nitrogen, and C-reactive protein levels were observed in non-survivors.
Each unit increase in UHR was associated with a 55% higher hazard of in-hospital mortality (HR: 1.55; 95% CI: 1.18-2.01, p=0.002).
The association was stronger in older patients and those with higher serum creatinine and elevated CRP levels.
Interpretation:
UHR independently predicts in-hospital mortality in AKI.
Limitations:
The study was conducted at a single center, which may limit generalizability.
Retrospective design may introduce biases in data collection and analysis.
Conclusion:
UHR may serve as a prognostic marker for in-hospital mortality in AKI patients.
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