To deepen the understanding of the initiation and progression of pancreatic cancer and to provide new directions for its early diagnosis and precision treatment.
Approach:
Key Findings:
Pancreatic cancer has a high mortality rate and is projected to increase significantly by 2040.
Most patients are diagnosed at an advanced stage, with over 80% deemed unresectable.
The disease is characterized by strong invasiveness, resistance to treatment, and a low 5-year survival rate.
Precancerous lesions such as PanIN, IPMN, and MCN play a crucial role in the progression to invasive pancreatic cancer.
Interpretation:
The etiology and pathogenesis of pancreatic cancer remain unclear, necessitating a comprehensive analysis of risk factors and molecular events.
Limitations:
Current studies primarily focus on epidemiological risk factors without fully explaining the pathogenesis.
There is a need for more integrated analyses of pathological precursor lesions and driver genes.
Conclusion:
Identifying safe and effective therapeutic strategies for pancreatic cancer is an urgent clinical challenge.
