To evaluate the relationship between oxidative stress, antioxidants, and breast cancer progression and treatment.
Approach:
Key Findings:
Oxidative stress from ROS imbalance promotes DNA damage and drives breast cancer initiation and progression.
Antioxidants help maintain ROS homeostasis and may protect against cancer development.
ROS can induce apoptosis and are used as therapeutic agents against cancer.
Plant-derived antioxidants may alleviate chemotherapy side effects.
Some antioxidants may paradoxically promote tumor progression.
Interpretation:
Oxidative stress plays a significant role in breast cancer development, while antioxidants have complex roles that can both protect against and promote cancer.
Limitations:
Conflicting information exists regarding the roles of ROS and antioxidants in breast cancer.
The concept of persistent oxidative stress in cancer cells requires further research.
Conclusion:
The review highlights the dual roles of ROS and antioxidants in breast cancer, emphasizing the need for further investigation into their complex interactions.
