Ovarian endometriosis associated with significantly elevated CA19-9: a case report - Summary - MDSpire

Significant Elevation of CA19-9 in a Case of Ovarian Endometriosis: A Clinical Report

  • By

  • Yue Hu

  • Jiali Ruan

  • Xuelian Du

  • July 21, 2026

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Objective:

To report a case of significantly elevated CA19-9 in a patient with ovarian endometriosis, highlighting the rarity of this occurrence in benign conditions and providing clinical evidence for the differential diagnosis of benign and malignant ovarian lesions.

Approach:
  • Case Presentation: A 44-year-old female with a history of ovarian cysts presented with elevated CA19-9 levels (up to 2453.1 U/mL) and pelvic symptoms, including left lower abdominal pain and weight loss. Extensive workup, including gastroenterological endoscopy and abdominal MRI, excluded gastrointestinal malignancies, and laparoscopy confirmed ovarian endometriosis.
Key Findings:
  • CA19-9 level was significantly elevated at 2453.1 U/mL in a case of ovarian endometriosis.
  • The patient had a long-standing history of ovarian cysts and presented with abdominal pain and weight loss.
  • Postoperative follow-up showed normalization of CA19-9 levels with no lesion recurrence.
Interpretation:

Elevated CA19-9 levels in benign conditions like ovarian endometriosis can complicate diagnosis.

Limitations:
  • The case report is based on a single patient, limiting generalizability.
  • The exact pathophysiological mechanism for elevated CA19-9 in ovarian endometriosis remains unclear.
Conclusion:

Elevated CA19-9 in female patients with ovarian cysts and pelvic symptoms warrants careful evaluation to differentiate between benign and malignant conditions.

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