Clinical benefit of paclitaxel/carboplatin plus bevacizumab with zoledronic acid in pulmonary epithelioid hemangioendothelioma complicated by hypertrophic pulmonary osteoarthropathy and cardiac tamponade: a case report - Summary - MDSpire

Clinical benefit of paclitaxel/carboplatin plus bevacizumab with zoledronic acid in pulmonary epithelioid hemangioendothelioma complicated by hypertrophic pulmonary osteoarthropathy and cardiac tamponade: a case report

  • By

  • Saki Tsuchimochi

  • Hiromichi Nakajima

  • Yukako Hattori

  • Shioto Oda

  • Hiroki Imada

  • Tetsuro Taki

  • Anna Matsuoka

  • Shogo Watanabe

  • Akira Hirota

  • Mai Shimura

  • Misao Fukuda

  • Chikako Funasaka

  • Kenichi Harano

  • Nobuaki Matsubara

  • Yoichi Naito

  • Ako Hosono

  • Genichiro Ishii

  • Toru Mukohara

  • June 2, 2026

  • 0 min

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Objective:

To report a case of advanced pulmonary epithelioid hemangioendothelioma (PEH) complicated by hypertrophic pulmonary osteoarthropathy (HPOA) and cardiac tamponade, and to evaluate the efficacy of a combined treatment approach based on clinical outcomes and imaging results.

Key Findings:
  • Histopathology confirmed the diagnosis of epithelioid hemangioendothelioma, highlighting the tumor's vascular characteristics.
  • The combination of systemic chemotherapy and bevacizumab contributed to temporary control of effusions, suggesting a potential treatment pathway.
  • Zoledronic acid may have supported symptom improvement related to HPOA, indicating its role in managing paraneoplastic syndromes.
Interpretation:

The case suggests that systemic chemotherapy combined with anti-VEGF therapy may provide clinical benefits in advanced PEH, particularly in managing associated symptoms.

Limitations:
  • The benefits observed were transient and require further investigation; the study is based on a single case report, limiting generalizability and introducing potential biases.
Conclusion:

This case highlights the potential for combined therapies in managing advanced PEH and associated complications.

Original Source(s)

Clinical benefit of paclitaxel/carboplatin plus bevacizumab with zoledronic acid in pulmonary epithelioid hemangioendothelioma complicated by hypertrophic pulmonary osteoarthropathy and cardiac tamponade: a case report

  • by Saki Tsuchimochi, Hiromichi Nakajima, Yukako Hattori, Shioto Oda, Hiroki Imada, Tetsuro Taki, Anna Matsuoka, Shogo Watanabe, Akira Hirota, Mai Shimura, Misao Fukuda, Chikako Funasaka, Kenichi Harano, Nobuaki Matsubara, Yoichi Naito, Ako Hosono, Genichiro Ishii, Toru Mukohara

  • June 2, 2026

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