Case Report: Cardiac metastasis from urothelial carcinoma with predominant squamous differentiation in a young woman: first reported case treated with enfortumab vedotin plus pembrolizumab - Summary - MDSpire

Case Report: Cardiac metastasis from urothelial carcinoma with predominant squamous differentiation in a young woman: first reported case treated with enfortumab vedotin plus pembrolizumab

  • By

  • Alix Vansteeger

  • El Mamoune El Ghali Benlemlih

  • Antoine Delmarche

  • Stéphane Thiry

  • Hélène Dano

  • Justine Castaigne

  • Vassiliki Pasoglou

  • Sandy Van Nieuwenhove

  • Bernhard Gerber

  • Gaby Aphram

  • Qaid Ahmed Shagera

  • Christophe Beauloye

  • Rachel Galot

  • Cédric van Marcke

  • Emmanuel Seront

  • May 20, 2026

  • 0 min

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Objective:

To report a case of a young woman with cardiac metastasis from urothelial carcinoma exhibiting predominant squamous differentiation and to discuss treatment implications in the context of existing literature.

Key Findings:
  • Cardiac metastases from urothelial carcinoma are rare and associated with poor prognosis, highlighting the need for awareness in clinical practice.
  • The patient exhibited predominant squamous differentiation in both the bladder and cardiac lesions, suggesting aggressive tumor biology.
  • Urgent surgical intervention was necessary due to impending right ventricular outflow obstruction, raising questions about the balance between surgical and systemic treatment.
Interpretation:

The case highlights the aggressive nature of squamous-dominant metastatic urothelial carcinoma and the challenges in managing cardiac involvement, suggesting a need for further research into treatment strategies.

Limitations:
  • Limited evidence exists for the efficacy of enfortumab vedotin in squamous-predominant metastatic urothelial carcinoma, and the rarity of such cases limits generalizability.
  • The patient's rapid deterioration post-treatment limits conclusions about the effectiveness of the therapy.
Conclusion:

This case underscores the need for careful cardiac evaluation in patients with urothelial carcinoma and the complexities of treatment in cases with cardiac metastasis, emphasizing the necessity for further research in this area.

Original Source(s)

Case Report: Cardiac metastasis from urothelial carcinoma with predominant squamous differentiation in a young woman: first reported case treated with enfortumab vedotin plus pembrolizumab

  • by Alix Vansteeger, El Mamoune El Ghali Benlemlih, Antoine Delmarche, Stéphane Thiry, Hélène Dano, Justine Castaigne, Vassiliki Pasoglou, Sandy Van Nieuwenhove, Bernhard Gerber, Gaby Aphram, Qaid Ahmed Shagera, Christophe Beauloye, Rachel Galot, Cédric van Marcke, Emmanuel Seront

  • May 20, 2026

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