Prognostic value of the TAPSE/PASP-ratio in patients with severe mitral regurgitation undergoing transcatheter edge-to-edge mitral valve repair - Summary - MDSpire
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Prognostic value of the TAPSE/PASP-ratio in patients with severe mitral regurgitation undergoing transcatheter edge-to-edge mitral valve repair
To investigate the prevalence of RV-PA uncoupling in patients undergoing M-TEER and its potential value as a discriminator of long-term survival.
Approach:
Study Design: Monocentric retrospective cohort study of patients who underwent M-TEER.
Patient Selection: Patients deemed ineligible for surgical mitral valve repair were included, with echocardiographic suitability confirmed.
Outcome Measurement: Primary endpoint was mortality during the follow-up period, with RV-PA uncoupling defined as a TAPSE/D-PASP ratio < 0.37 mm/mmHg.
Statistical Analysis: Utilized R Studio for statistical analyses, including Kaplan-Meier method for survival and Cox regression for mortality predictors.
Key Findings:
RV-PA uncoupling was present in 32.3% of the 158 patients analyzed.
The median follow-up period was 499 ± 832 days.
Loss to follow-up was 5.1%, with no significant difference between patients with and without RV-PA uncoupling (9.8% vs. 2.8%, p = 0.1).
Interpretation:
The study reports the prevalence of RV-PA uncoupling in patients undergoing M-TEER.
Limitations:
Retrospective nature of the study may introduce bias.
Inconsistent definitions of RV-PA uncoupling across studies.
Conclusion:
The findings indicate that RV-PA uncoupling may be associated with long-term survival in patients undergoing M-TEER.
