Glycocalyx Biomarkers as Early Predictors of Endotheliopathy in Pediatric and Young Adult Hematopoietic Stem Cell Transplantation Patients - Summary - MDSpire

Glycocalyx Biomarkers as Early Predictors of Endotheliopathy in Pediatric and Young Adult Hematopoietic Stem Cell Transplantation Patients

  • By

  • Uchida, Kimberly

  • Mahadeo, Kris Michael

  • McArthur, Jennifer Ann

  • Avent, Yvonne

  • Hsu, Chia-Wei

  • Pan, Haitao

  • Elbahlawan, Lama

  • Hines, Melissa R

  • Sharma, Akshay

  • Tatevossian, Ruth G

  • Mahapatra, Sebabrata

  • Kumbaji, Meenasri

  • Sheikh, Irtiza

  • Li, Ying

  • Schadler, Keri

  • Ghafoor, Saad

  • April 13, 2026

  • 0 min

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Objective:

To assess the concentrations and predictive abilities of glycocalyx biomarkers for endotheliopathy during the initial 100 days after HSCT in pediatric and young adult populations.

Key Findings:
  • Syndecan-1 and Angiopoietin-2 levels differed significantly between endotheliopathy cases and controls at multiple time points in the SJCRH study.
  • Predictive values for Syndecan-1 and Angiopoietin-2 were good to excellent prior to endotheliopathy diagnosis.
  • MDACC identified a biomarker signature associated with endotheliopathy on Days 0 and 7, with TIMP-1 and IGFBP-3 showing perfect predictive performance.
Interpretation:

Glycocalyx biomarkers are promising for early prediction of endotheliopathy in pediatric and young adult HSCT patients, highlighting the importance of endothelial injury in post-transplant complications.

Limitations:
  • Limited sample size may affect generalizability of findings.
  • Further research is needed to validate results in larger populations.
Conclusion:

The studies underscore the potential of glycocalyx biomarkers as early indicators of endotheliopathy, warranting further investigation.

Original Source(s)

Glycocalyx Biomarkers as Early Predictors of Endotheliopathy in Pediatric and Young Adult Hematopoietic Stem Cell Transplantation Patients

  • by Uchida, Kimberly , Mahadeo, Kris Michael, McArthur, Jennifer Ann, Avent, Yvonne , Hsu, Chia-Wei , Pan, Haitao , Elbahlawan, Lama , Hines, Melissa R, Sharma, Akshay , Tatevossian, Ruth G, Mahapatra, Sebabrata , Kumbaji, Meenasri , Sheikh, Irtiza , Li, Ying , Schadler, Keri , Ghafoor, Saad

  • April 13, 2026

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