To investigate the impact of retained gallbladders on antimicrobial resistance patterns and clinical outcomes, including length of culture positivity and mortality rates, in patients with Pseudomonas aeruginosa bloodstream infections (PABSI).
Key Findings:
No significant differences in length of culture positivity, 90-day mortality, or in-hospital mortality between patients with and without a gallbladder, indicating that gallbladder status does not influence these outcomes.
Overall composite 90-day mortality was 30.1%, consistent with prior studies, highlighting the persistent risk associated with PABSI.
Patients with PABSI and liver disease had significantly higher 90-day mortality, suggesting the need for targeted interventions in this subgroup.
Interpretation:
Remote cholecystectomy does not influence the antimicrobial resistance profile or clinical outcomes in patients with PABSI, although high mortality rates persist, underscoring the need for improved treatment strategies.
Limitations:
Retrospective design may introduce bias, and potential confounding factors such as comorbidities were not fully controlled.
Single-center study limits generalizability, necessitating further multicenter research.
Conclusion:
Despite advances in treatment, mortality rates for PABSI remain high, and gallbladder status does not appear to affect outcomes, indicating a critical area for future research.
