To identify joint longitudinal trajectories of physio-cognitive aging and evaluate the relationship between physical and cognitive decline in relation to incident dementia.
Key Findings:
Identified four phenotypes of aging, including 'Dual Rapid Decliners' (10%) with a nearly five-fold increased risk of incident dementia (HR=4.85).
Physical decline significantly predicted subsequent cognitive decline, while the reverse was weak and non-significant.
Life space constriction mediated 16.8% of the relationship between physical and cognitive decline.
Concurrent vision impairment exacerbated the risk of cognitive decline.
Interpretation:
Objective physical decline is an early, independent prodromal marker for dementia, highlighting the importance of maintaining physical mobility and addressing sensory deficits.
Limitations:
Conclusion:
The study emphasizes the need for strategies to preserve cognitive health through physical mobility and sensory correction.
First CAR-T approach for Alzheimer’s reduces amyloid plaques in mice, while cell and gene therapies advance across blood cancers, retinal disease, amyloidosis, and FSHD
