Objective:

To investigate the effects of didymin on neurological outcomes, neuroinflammation, and blood-brain barrier (BBB) integrity after subarachnoid hemorrhage (SAH).

Approach:

Key Findings:

• Didymin treatment significantly improved neurological function scores in SAH rats.
• Didymin reduced neuroinflammation by inhibiting microglial activation and pro-inflammatory cytokine expression.
• Didymin preserved BBB integrity and alleviated brain edema by downregulating MMP9 expression.
• In the Hb-induced cell model, didymin suppressed MMP9 expression and promoted tight junction protein expression.

Interpretation:

Didymin treatment improved neurological function and reduced neuroinflammation and BBB disruption following SAH.

Conclusion:

Didymin demonstrates potential effects on neurological outcomes and neuroinflammation in the context of SAH.

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