Historical redlining, breast cancer survival, and the mediating and modifying role of contemporary neighborhood socioeconomic conditions - Summary - MDSpire
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Historical redlining, breast cancer survival, and the mediating and modifying role of contemporary neighborhood socioeconomic conditions
To investigate the mediating and modifying effects of contemporary neighborhood socioeconomic conditions on the relationship between historical redlining and breast cancer survival, specifically focusing on disparities in outcomes.
Key Findings:
The total effect risk ratio (RR) on 5-year mortality from D-grade vs A-grade was 1.20 (95% CI, 1.09-1.31).
Contemporary neighborhood socioeconomic conditions mediate approximately half the association between historical redlining and all-cause breast cancer survival.
Significant interaction was not detected across the entire cohort; however, results varied by race/ethnicity and tumor characteristics.
Interpretation:
Historical redlining has a significant impact on breast cancer survival, with contemporary neighborhood socioeconomic conditions playing a crucial mediating role.
Limitations:
The study is limited to female invasive first primary breast cancer cases diagnosed in New York State, which may not be generalizable to other populations.
Neighborhood boundaries in HOLC maps may not align with contemporary census tracts, complicating the analysis and potentially affecting the results.
Conclusion:
Interventions addressing contemporary neighborhood socioeconomic conditions, such as improving access to healthcare and economic resources, may help reduce breast cancer survival disparities linked to historical redlining.
by Sarah M Lima, Tia M Palermo, Lili Tian, Furrina F Lee, Tabassum Z Insaf, Jr Henry Louis Taylor, Helen C S Meier, Deborah O Erwin, Heather M Ochs-Balcom
