To evaluate time-based trends in renal parameters and serum calcium levels during the first 72 hours of life in neonates with birth asphyxia and their association with the severity of hypoxic-ischaemic encephalopathy (HIE).
Approach:
Study Design: A prospective observational cohort study conducted on 158 term neonates with birth asphyxia at a tertiary care facility.
Data Collection: Renal function parameters and serum calcium levels were measured at admission, 48 hours, and 72 hours of life.
Statistical Analysis: Data were analyzed using SPSS V.25, employing descriptive tests and multivariate logistic regression.
Key Findings:
AKI was observed in 88 out of 158 (55.7%) neonates.
Hypocalcaemia was found in 92 out of 158 (58.2%) neonates.
Elevated serum creatinine was noted in 110 out of 158 (69.6%) neonates.
Elevated urea was noted in 104 out of 158 (65.8%) neonates.
Serum creatinine and urea levels peaked at 48 hours, while serum calcium levels declined significantly within the first 48 hours.
Interpretation:
The study reports a high incidence of AKI and hypocalcaemia in neonates with birth asphyxia.
Limitations:
The study was conducted at a single tertiary care facility, which may limit generalizability.
The sample size was relatively small and limited to term neonates.
Conclusion:
The study highlights the importance of biochemical monitoring in neonates with birth asphyxia.
