Effectiveness, acceptability, adherence, and safety of exergaming for depressive symptoms: a systematic review and meta-analysis
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By
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Di Tang
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Chang Liu
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Jinde Liu
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Tong Liu
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Ruisi Ma
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Kim-wai Raymond Sum
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February 25, 2026
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Objective:
To evaluate the effectiveness, safety, acceptability, adherence, and cost-effectiveness of exergaming interventions for depressive symptoms.
Key Findings:
- Exergaming resulted in a moderate, significant reduction in depression symptoms (g = −0.40, 95% CI: −0.56 to −0.25, p < 0.0001).
- Larger effects were observed with intervention frequency greater than three times per week.
- Significant effects were noted in older adults (≥60 years) with a trend toward significance for age (p = 0.07).
- High adherence rates and a good safety profile were reported.
- Exergaming interventions were found to be reasonably cost-effective.
Interpretation:
Exergaming is a promising intervention for reducing depressive symptoms, particularly in older adults and with frequent engagement.
Limitations:
- The evidence remains inconsistent across studies.
- Future larger-scale randomized controlled trials are needed to confirm findings.
- Extended follow-up periods are required to evaluate long-term sustainability.
Conclusion:
Exergaming interventions show potential as effective, safe, and acceptable treatments for depression, warranting further research.
