Atherogenic index of plasma and severe headaches or migraines risk in US adults: a population-based cross-sectional analysis from NHANES 1999–2004 - Summary - MDSpire
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Atherogenic index of plasma and severe headaches or migraines risk in US adults: a population-based cross-sectional analysis from NHANES 1999–2004
To explore the association between the atherogenic index of plasma (AIP) and self-reported severe headaches or migraines using NHANES data.
Key Findings:
Among 1,218 severe headache or migraine patients, 57.6% were younger than 45 years, 57.6% were female, and 56.6% were smokers.
Higher risk of severe headaches or migraines was observed in the second (Q2: 26.5%) and fourth quartiles (Q4: 27.2%) of AIP.
After adjustment, Q2 (OR = 1.481) and Q4 (OR = 1.799) exhibited significantly elevated risks compared to Q1.
RCS analysis indicated a significant overall association between AIP and severe headaches or migraines (p = 0.029).
Subgroup analyses showed higher risks in individuals aged <45 years (OR = 1.50), female (OR = 1.47), and those without diabetes (OR = 1.31) or coronary heart disease (OR = 1.26).
XGBoost modeling identified AIP (19.34%) as a highly influential feature associated with severe headaches or migraines.
Interpretation:
Elevated AIP was associated with self-reported severe headaches or migraines, though a consistent dose-response relationship was not established, indicating the need for caution in interpretation.
Limitations:
The study is cross-sectional, limiting causal inference.
Self-reported data may introduce bias, affecting the reliability of the findings.
Conclusion:
These findings suggest a potential link between AIP and severe headaches or migraines, warranting further prospective studies.
