Non-linear and context-dependent association of maternal BMI with cumulative live birth in Chinese women undergoing intrauterine insemination: a retrospective study of 3788 cycles - Summary - MDSpire
Advertisement
Non-linear and context-dependent association of maternal BMI with cumulative live birth in Chinese women undergoing intrauterine insemination: a retrospective study of 3788 cycles
To evaluate the independent associations between maternal body mass index (BMI) and intrauterine insemination (IUI) outcomes, focusing on non-linear patterns, clinical thresholds, and population-specific heterogeneities.
Key Findings:
Maternal BMI showed no significant independent association with clinical pregnancy or live birth in the first cycle.
Per-cycle analysis revealed a modest positive correlation between BMI and pregnancy (aOR 1.04, P = 0.004) and live birth (aOR 1.03, P = 0.030).
Cumulative success followed a non-linear pattern, with live birth probability increasing until a BMI of approximately 21.2 kg/m² (aHR: 1.12, P = 0.007) and plateauing thereafter.
Subgroup analyses indicated heterogeneities in associations across basal FSH levels and treatment protocols.
Interpretation:
Maternal BMI exhibits a non-linear, context-dependent association with cumulative IUI success, suggesting the need for individualized preconception management.
Limitations:
Conclusion:
The study highlights the complex relationship between maternal BMI and IUI outcomes, emphasizing the importance of considering individual patient characteristics.
These 10 states make it more practical for physicians to participate in hospital ownership by aligning statutory structure, corporate practice of medicine rules, and population trends.
