Objective:

To report a case of successful early CRRT implementation for severe AKI secondary to perinatal asphyxia in a VLBW infant and review relevant literature, highlighting its significance in clinical practice.

Approach:

Key Findings:

• CRRT was initiated approximately 20 hours after birth using a low initial blood flow rate.
• After 37 hours of CRRT, urine output increased significantly, and serum creatinine and blood urea nitrogen levels decreased, indicating improved renal function.
• The infant was weaned from CRRT and invasive mechanical ventilation and discharged in stable condition, demonstrating the potential benefits of early intervention.

Interpretation:

Early and graduated CRRT intervention may contribute to maintaining hemodynamic stability and facilitating organ function recovery in VLBW infants with AKI, suggesting a need for further research.

Limitations:

• Evidence supporting CRRT for shock-associated AKI in VLBW/ELBW preterm infants is limited to single-center case reports and small case series, which may affect the applicability of findings.
• Standardized recommendations regarding CRRT initiation timing and management are lacking, highlighting the need for further guidelines.

Conclusion:

Meticulous peri-CRRT management is essential to ensure treatment safety in VLBW infants with AKI, emphasizing the importance of individualized strategies.

Attribution Notice

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.