To assess associations of PCOS, dietary intervention, and gestational weight loss with specific maternal and neonatal outcomes in women with GDM, including glycemia and weight change.
Key Findings:
Women with GDM and PCOS had similar baseline characteristics, glycemia, BMI, and pregnancy outcomes compared to those without PCOS, but infants of women with GDM and PCOS had significantly higher rates of neonatal jaundice (24.4% vs 8.9%, P = .002).
PCOS was not associated with increased risks for most suboptimal pregnancy outcomes or reduced efficacy of dietary intervention.
Interpretation:
The presence of PCOS in women with GDM does not significantly worsen pregnancy outcomes or dietary intervention efficacy in this cohort, suggesting that management strategies can remain consistent regardless of PCOS status.
Limitations:
Self-reported PCOS status may introduce bias, potentially affecting the reliability of the findings.
The study's sample size may limit the generalizability of the findings, necessitating further research with larger cohorts.
Conclusion:
PCOS does not appear to exacerbate risks in women with GDM when controlling for glycemia and BMI, suggesting dietary interventions are equally effective regardless of PCOS status, highlighting the need for further research to confirm these findings.
