HIV-related Differences in Placental Immunology: Data From the PRACHITi Cohort in Pune, India - Summary - MDSpire

HIV-related Differences in Placental Immunology: Data From the PRACHITi Cohort in Pune, India

  • By

  • Jyoti S Mathad

  • Mallika Alexander

  • Ramesh Bhosale

  • Shilpa Naik

  • Lisa Marie Cranmer

  • Vandana Kulkarni

  • Sydney Busch

  • Andrea Chalem

  • Emily Gitlin

  • Jun Lei

  • Anguo Liu

  • Jin Liu

  • Yang Liu

  • Rupak Shivakoti

  • Amita Gupta

  • Irina Burd

  • January 31, 2025

  • 0 min

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Objective:

To delineate differences in placental FcRn and T-cell expression by HIV status, considering the impact of viral suppression.

Key Findings:
  • Relative placental FcRn expression was lower in women living with HIV compared to those without (median 0.54 vs 0.84, P = .01).
  • Women with HIV had significantly higher abundance of placental CD8+ T cells, regardless of viral suppression (P < .05).
Interpretation:

Maternal HIV, even with viral suppression, is associated with lower placental FcRn expression and increased placental CD8+ T cells, suggesting that antiretroviral therapy may not fully reverse immune dysregulation, impacting clinical outcomes.

Limitations:
  • Small sample size of placental biopsies (42), which may limit the generalizability of the findings.
  • Observational nature limits causal inferences, necessitating further research.
Conclusion:

The findings indicate that dysregulation in placental immunology persists in women living with HIV, potentially contributing to poorer infant outcomes despite viral suppression, highlighting the need for ongoing monitoring and intervention.

Original Source(s)

HIV-related Differences in Placental Immunology: Data From the PRACHITi Cohort in Pune, India

  • by Jyoti S Mathad, Mallika Alexander, Ramesh Bhosale, Shilpa Naik, Lisa Marie Cranmer, Vandana Kulkarni, Sydney Busch, Andrea Chalem, Emily Gitlin, Jun Lei, Anguo Liu, Jin Liu, Yang Liu, Rupak Shivakoti, Amita Gupta, Irina Burd

  • January 31, 2025

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