Immunohistochemistry vs Molecular Breast Cancer Subtyping Among African Populations - Summary - MDSpire
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Comparing Immunohistochemical and Molecular Breast Cancer Subtyping in African Populations

  • By

  • Shahin Sayed

  • Li Feng

  • Hela Koka

  • Manel Haj Mansour

  • Difei Wang

  • Maria Brown

  • Kristine Jones

  • Margaret Maina

  • Veronica Ngundo

  • Alfred Mburu Githuka

  • Zaitun Ajuoga

  • Shaoqi Fan

  • Amber N. Hurson

  • Xing Hua

  • Petra Lenz

  • Rosemary Wangari Kamau

  • Beryl Akinyi Ooro

  • Francis Makokha

  • Stefan Ambs

  • Aaron M. Rozeboom

  • Amy Hutchinson

  • Belynda Hicks

  • Mustapha Abubakar

  • Xiaohong R. Yang

  • October 12, 2026

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Objective:

To assess how well IHC-based breast cancer subtype classifications agree with PAM50 molecular subtypes in Kenyan patients and validate the findings in a Ghanaian cohort.

Approach:
  • Design and cohorts: Cross-sectional analysis of 460 patients with invasive breast cancer in Kenya, with validation in 451 women from the Ghana Breast Health Study.
  • Subtype assessment: Tumors were classified using IHC markers (ER, PR, ERBB2, and Ki-67) and histologic grade, and compared with PAM50 gene-expression subtypes.
  • Analysis: Agreement was assessed using sensitivity, specificity, and Cohen κ; analyses were stratified by hospital site and study. Duplicate assays in 44 patients were used to examine profiling concordance.
Key Findings:
  • The supplied context describes the study design and planned analyses but does not include study results or agreement estimates.
Interpretation:

The study evaluates whether IHC-based surrogate classifications correspond to PAM50 subtypes in Kenyan and Ghanaian cohorts; the provided text does not include the results needed to characterize the degree of agreement.

Limitations:
  • The supplied context is truncated before the results and does not provide detailed findings or study limitations.
Sources:

Original Source(s)

Immunohistochemistry vs Molecular Breast Cancer Subtyping Among African Populations

  • by Shahin Sayed, Li Feng, Hela Koka, Manel Haj Mansour, Difei Wang, Maria Brown, Kristine Jones, Margaret Maina, Veronica Ngundo, Alfred Mburu Githuka, Zaitun Ajuoga, Shaoqi Fan, Amber N. Hurson, Xing Hua, Petra Lenz, Rosemary Wangari Kamau, Beryl Akinyi Ooro, Francis Makokha, Stefan Ambs, Aaron M. Rozeboom, Amy Hutchinson, Belynda Hicks, Mustapha Abubakar, Xiaohong R. Yang

  • October 12, 2026

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