Chronic inflammatory demyelinating polyneuropathy (CIDP) after cilta-cel therapy - Summary - MDSpire

Chronic inflammatory demyelinating polyneuropathy (CIDP) after cilta-cel therapy

  • By

  • M. Korenkov

  • J. Liebaert

  • S. Yousefian

  • S. Schwartz

  • U. M. Demel

  • J. Braune

  • M. C. Odabasi

  • L. Herzberg

  • D. Böckle

  • N. C. Görür

  • V. v. Landenberg-Roberg

  • S. Bohl

  • E. Tregel

  • S. Hennig

  • C. Franke

  • S. Haas

  • U. Keller

  • J. Krönke

  • A. Busse

  • October 20, 2025

  • 0 min

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Objective:

To report cases of CIDP following cilta-cel therapy in patients with relapsed multiple myeloma, highlighting the clinical significance of these findings.

Key Findings:
  • Both patients developed CIDP with varying onset times post cilta-cel infusion, with detailed clinical assessments indicating mixed sensorimotor axonal demyelinating polyneuropathy.
  • Patient 1 experienced progressive neurological decline and succumbed to complications, while Patient 2 showed gradual improvement and significant recovery.
  • CAR-T cells were detected in the peripheral blood and CSF of both patients, with differing kinetics and responses to treatment, correlating with clinical outcomes.
Interpretation:

CIDP can occur as a delayed neurological complication following CAR-T cell therapy, underscoring the need for vigilant monitoring and a deeper understanding of the immunopathology involved.

Limitations:
  • The rarity of CIDP cases limits generalizability.
  • Long-term outcomes and mechanisms remain unclear due to limited patient data, necessitating further research.
Conclusion:

CIDP may represent a rare but significant complication of cilta-cel therapy, necessitating urgent investigation into its pathophysiology and management strategies.

Original Source(s)

Chronic inflammatory demyelinating polyneuropathy (CIDP) after cilta-cel therapy

  • by M. Korenkov, J. Liebaert, S. Yousefian, S. Schwartz, U. M. Demel, J. Braune, M. C. Odabasi, L. Herzberg, D. Böckle, N. C. Görür, V. v. Landenberg-Roberg, S. Bohl, E. Tregel, S. Hennig, C. Franke, S. Haas, U. Keller, J. Krönke, A. Busse

  • October 20, 2025

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