Artificial intelligence in rehabilitation: a review of clinical effectiveness, real-world performance, safety, and equity across modalities and settings - Summary - MDSpire

Artificial intelligence in rehabilitation: a review of clinical effectiveness, real-world performance, safety, and equity across modalities and settings

  • By

  • Nafisa Abdalla

  • Rabie Adel El Arab

  • Amany Abdrbo

  • Mohammed Almari

  • Mohammed Yahya Ayoub

  • Bilal Alsaaideh

  • Mohammad Suhail Dagamseh

  • Wesam Taher Almagharbeh

  • Fuad Abuadas

  • Mohammad S. Abu Mahfouz

  • Mastoura Khames Gaballah

  • March 18, 2026

  • 0 min

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Objective:

To provide a comprehensive overview of artificial-intelligence–enabled rehabilitation and assess its clinical usefulness, safety, equity, and cost across various modalities.

Key Findings:
  • Technology-assisted training (robotics with or without VR) shows reproducible activity improvement for post-stroke upper limb rehabilitation.
  • Inconsistent effects on impairment and independence were noted when dose was matched and assessors blinded.
  • AI-enabled interventions often experience degradation in performance from development to deployment, particularly in brain-computer interfaces and computer vision.
  • Imaging-based decision support tools require local calibration and evaluation before clinical implementation.
  • Reported adverse events are generally mild, but usability, adherence, equity, and cost are under-researched.
Interpretation:

AI has the potential to enhance rehabilitation services but requires rigorous validation, safety measures, and equitable access to ensure effectiveness across diverse populations and settings.

Limitations:
  • Generalizability of AI models is a concern due to performance degradation across different environments.
  • Inconsistent safety and usability reporting, especially for home and hybrid rehabilitation pathways.
  • Lack of subgroup performance reporting and skewed representation towards high-income settings, leaving low-income populations underrepresented.
Conclusion:

AI can expand rehabilitation access and independence when adhering to clinical standards, with clear adoption criteria and ongoing monitoring to ensure safety, equity, and effectiveness.

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