Multiple myeloma and SARS-CoV-2 infection: clinical characteristics and prognostic factors of inpatient mortality - Summary - MDSpire

Multiple myeloma and SARS-CoV-2 infection: clinical characteristics and prognostic factors of inpatient mortality

  • By

  • Joaquín Martínez-López

  • María-Victoria Mateos

  • Cristina Encinas

  • Anna Sureda

  • José Ángel Hernández-Rivas

  • Ana Lopez de la Guía

  • Diego Conde

  • Isabel Krsnik

  • Elena Prieto

  • Rosalía Riaza Grau

  • Mercedes Gironella

  • María Jesús Blanchard

  • Nerea Caminos

  • Carlos Fernández de Larrea

  • María Alicia Senin

  • Fernando Escalante

  • José Enrique de la Puerta

  • Eugenio Giménez

  • Pilar Martínez-Barranco

  • Juan José Mateos

  • Luis Felipe Casado

  • Joan Bladé

  • Juan José Lahuerta

  • Javier de la Cruz

  • Jesús San-Miguel

  • October 19, 2020

  • 0 min

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Objective:

To describe the clinical characteristics of COVID-19 in hospitalized multiple myeloma (MM) patients, compare outcomes with a noncancer cohort to highlight the significance of these comparisons, and identify preadmission prognostic factors of inpatient mortality.

Key Findings:
  • 216 patients with MM and SARS-CoV-2 infection were reported from 73 healthcare centers, indicating a significant patient population.
  • Increased age, male sex, and comorbidities were significant factors associated with higher mortality, suggesting targeted interventions may be necessary.
  • MM patients exhibited impaired humoral and cellular immunity, increasing susceptibility to infections, which underscores the need for vigilant monitoring.
Interpretation:

MM patients are at heightened risk for severe COVID-19 outcomes due to compromised immune systems and treatment-related factors, necessitating tailored management strategies, such as adjusting treatment protocols and enhancing supportive care.

Limitations:
  • Limited data on MM patients with COVID-19 prior to this study may affect the generalizability of the findings.
  • Potential biases in patient selection and data collection methods could influence the results and interpretations.
Conclusion:

This study provides critical insights into the clinical characteristics and mortality risk factors for MM patients infected with SARS-CoV-2, highlighting the need for specific guidelines in managing these patients during the pandemic, which could improve patient outcomes.

Original Source(s)

Multiple myeloma and SARS-CoV-2 infection: clinical characteristics and prognostic factors of inpatient mortality

  • by Joaquín Martínez-López, María-Victoria Mateos, Cristina Encinas, Anna Sureda, José Ángel Hernández-Rivas, Ana Lopez de la Guía, Diego Conde, Isabel Krsnik, Elena Prieto, Rosalía Riaza Grau, Mercedes Gironella, María Jesús Blanchard, Nerea Caminos, Carlos Fernández de Larrea, María Alicia Senin, Fernando Escalante, José Enrique de la Puerta, Eugenio Giménez, Pilar Martínez-Barranco, Juan José Mateos, Luis Felipe Casado, Joan Bladé, Juan José Lahuerta, Javier de la Cruz, Jesús San-Miguel

  • October 19, 2020

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