ADGRD1 promotes bladder cancer progression and angiogenesis via the PI3K/AKT/mTOR-mediated pro-angiogenic secretome
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By
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Chen Li
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Zhichao Yang
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Jialei Zhang
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Xiaodong Yan
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Hongwei Su
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May 28, 2026
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Objective:
To investigate the role of ADGRD1 in bladder cancer and its underlying signaling mechanisms.
Key Findings:
- ADGRD1 expression is significantly enriched in advanced-stage and high-grade BLCA.
- ADGRD1 serves as a robust predictor of poor overall survival and progression-free interval.
- ADGRD1 promotes BLCA cell proliferation, migration, invasion, and endothelial tube formation in vitro.
- ADGRD1 enhances tumor growth and angiogenesis in vivo.
- ADGRD1 activates the PI3K/AKT/mTOR signaling cascade, leading to increased phosphorylation of pathway components.
Interpretation:
Limitations:
- The study primarily relies on in vitro and in vivo models, which may not fully replicate human disease.
- Further clinical validation is needed to confirm ADGRD1 as a prognostic biomarker.
Conclusion:
