Reference Intervals for 24-Hour Urinary Calcium Excretion and Its Association With Bone Metabolism: A Multicenter Study - Summary - MDSpire

Reference Intervals for 24-Hour Urinary Calcium Excretion and Its Association With Bone Metabolism: A Multicenter Study

  • By

  • Li Shen

  • Hao Zhang

  • Qi Lu

  • Shanshan Li

  • Yazhao Mei

  • Chao Gao

  • Hua Yue

  • Xiangtian Yu

  • Qi Yao

  • Yanan Huo

  • Yuhong Zeng

  • Yin Jiang

  • Zhongjian Xie

  • Aijun Chao

  • Xiaolan Jin

  • Guangjun Yu

  • Li Mao

  • Zhenlin Zhang

  • February 28, 2025

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Objective:

To investigate the distribution of 24-hour urinary calcium excretion (UCaE) and its association with bone metabolism.

Key Findings:
  • The median 24-hour UCaE was 2.27 mmol overall, with variations by gender and age.
  • Men aged 30-44 years had the highest UCaE/Ucr, while women showed a gradual increase with age.
  • 24-hour UCaE/Ucr was positively associated with 25(OH)D in both genders and with PTH, β-CTX, and P1NP in men.
  • The prevalence of hypercalciuria was 11.6%, varying significantly across age groups and regions.
Interpretation:

The study established reference intervals for 24-hour UCaE in the Chinese population and highlighted gender differences in its relationship with bone metabolism.

Limitations:
  • The study excluded participants with various health conditions that may affect calcium metabolism.
  • Findings may not be generalizable beyond the Chinese population.
Conclusion:

This study provides important insights into urinary calcium excretion patterns and their implications for bone health in the Chinese adult population.

Original Source(s)

Reference Intervals for 24-Hour Urinary Calcium Excretion and Its Association With Bone Metabolism: A Multicenter Study

  • by Li Shen, Hao Zhang, Qi Lu, Shanshan Li, Yazhao Mei, Chao Gao, Hua Yue, Xiangtian Yu, Qi Yao, Yanan Huo, Yuhong Zeng, Yin Jiang, Zhongjian Xie, Aijun Chao, Xiaolan Jin, Guangjun Yu, Li Mao, Zhenlin Zhang

  • February 28, 2025

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