Long-term psychological and functional outcomes after hepatitis C eradication with direct-acting antivirals: an 80-month follow-up study - Summary - MDSpire
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Long-term psychological and functional outcomes after hepatitis C eradication with direct-acting antivirals: an 80-month follow-up study
To assess the long-term psychiatric and quality-of-life outcomes following hepatitis C treatment with direct-acting antivirals (DAAs) over an 80-month period, highlighting the significance of these outcomes.
Key Findings:
In Group P (patients with psychiatric history), depressive and anxiety symptoms significantly improved from baseline to follow-up.
Group NP (patients without psychiatric history) showed stable psychological profiles with significant reductions in depressive and anxiety symptoms.
Both groups experienced a significant decline in physical quality of life as measured by SF-36, indicating a need for further investigation into the causes.
Avoidant coping and psychiatric history were significant negative predictors of long-term anxiety change.
Interpretation:
Seven years after HCV eradication, psychological well-being remains stable or improved, while physical quality of life declines, suggesting a need for integrated care. DAAs demonstrate sustained long-term psychiatric safety.
Limitations:
Only 24 out of 62 patients were reassessed, which may limit the generalizability of the findings.
The study did not explore the impact of residual comorbidities and aging on quality of life, and potential biases in patient selection should be considered.
Conclusion:
The study highlights the need for integrated medical–psychological follow-up in HCV survivors, emphasizing the importance of ongoing psychological support.
by Salvatore Cipolla, Pierluigi Catapano, Maria Chiara Della Corte, Daniele De Francesco, Antonio Volpicelli, Iolanda Cafarella, Filomena Boccia, Lorenzo Bertolino, Emanuele Durante-Mangoni, Rosa Zampino, Mario Luciano
