Comparative Analysis of Roux-en-Y Gastric Bypass and Sleeve Gastrectomy on Cardiometabolic Health: A Systematic Review and Meta-Analysis of Randomized Trials - Summary - MDSpire

Comparative Analysis of Roux-en-Y Gastric Bypass and Sleeve Gastrectomy on Cardiometabolic Health: A Systematic Review and Meta-Analysis of Randomized Trials

  • By

  • Felipe Pereira Garrido Pazos

  • Rafael Matos Vieira Gordilho

  • Eduardo de Oliveira Novelli

  • Luiz Guilherme Lima Santana

  • Maria da Conceição Cavalcanti de Figueiredo Vilaboim

  • Breno Santos Matos de Magalhães

  • Maria Luisa França Lessa

  • Pedro Henrique Matos Oliveira

  • Marcelo Falcão

  • April 29, 2026

  • 0 min

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Objective:

To compare Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) regarding continuous metabolic markers (e.g., HbA1c, lipid profiles) and remission of cardiometabolic comorbidities across different follow-up periods.

Key Findings:
  • 24 studies met eligibility criteria for analysis.
  • RYGB showed superior outcomes in certain metabolic markers (e.g., HbA1c, triglycerides) compared to SG.
  • Long-term follow-up indicated variability in T2DM remission rates between the two procedures.
Interpretation:

RYGB may offer better long-term metabolic health benefits compared to SG, but results vary based on specific outcomes (e.g., T2DM remission) and follow-up duration.

Limitations:
  • Heterogeneity among studies regarding patient populations and outcomes, which may affect generalizability.
  • Limited long-term data for some outcomes, potentially impacting the robustness of conclusions.
Conclusion:

Both RYGB and SG are effective for obesity management, but RYGB may have advantages in certain cardiometabolic outcomes over time.

Original Source(s)

Comparative Analysis of Roux-en-Y Gastric Bypass and Sleeve Gastrectomy on Cardiometabolic Health: A Systematic Review and Meta-Analysis of Randomized Trials

  • by Felipe Pereira Garrido Pazos, Rafael Matos Vieira Gordilho, Eduardo de Oliveira Novelli, Luiz Guilherme Lima Santana, Maria da Conceição Cavalcanti de Figueiredo Vilaboim, Breno Santos Matos de Magalhães, Maria Luisa França Lessa, Pedro Henrique Matos Oliveira, Marcelo Falcão

  • April 29, 2026

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