To develop simplified and accurate bone age assessment (BAA) methods to aid pediatricians in quick clinical evaluations.
Key Findings:
The simplified 3-bone model (radius, ulna, and metacarpal I) achieved R² > 0.94 and root mean square error < 0.5 years.
When bone grades were consistent, a few bones could serve as proxies for bone age.
Incorporating puberty stages into models improved assessment accuracy.
Interpretation:
The study suggests that simplified BAA methods can enhance clinical efficiency and accuracy, particularly when considering puberty stages.
Limitations:
Further validation is needed to test the robustness of the models across different populations and scenarios, which is essential for broader clinical application.
The study's reliance on a single geographic location may limit generalizability, potentially affecting the applicability of the findings in diverse clinical settings.
Conclusion:
The proposed simplified 3-bone models could facilitate rapid and accurate bone age assessments in clinical settings.
Metabolomics analysis identified higher uric acid levels in patients with lipedema and lymphedema, although associations weakened following adjustment for renal insufficiency.
