HSP90 inhibitor NVP-BEP800 affects stability of SRC kinases and growth of T-cell and B-cell acute lymphoblastic leukemias - Summary - MDSpire

HSP90 inhibitor NVP-BEP800 affects stability of SRC kinases and growth of T-cell and B-cell acute lymphoblastic leukemias

  • By

  • Rony Mshaik

  • John Simonet

  • Aleksandra Georgievski

  • Layla Jamal

  • Shaliha Bechoua

  • Paola Ballerini

  • Pierre-Simon Bellaye

  • Zandile Mlamla

  • Jean-Paul Pais de Barros

  • Audrey Geissler

  • Pierre-Jean Francin

  • François Girodon

  • Carmen Garrido

  • Ronan Quéré

  • March 18, 2021

  • 0 min

Share

Objective:

To evaluate the effects of the HSP90 inhibitor NVP-BEP800 on SRC kinases and the growth of T-ALL and B-ALL.

Key Findings:
  • NVP-BEP800 inhibited LCK in T-ALL and LYN in B-ALL.
  • The drug reduced the viability of primary T-ALL and B-ALL cells in vitro.
  • NVP-BEP800 treatment inhibited leukemia cell development and proliferation in xenografted mouse models.
Interpretation:

NVP-BEP800 shows potential as a therapeutic agent for T-ALL and B-ALL by targeting key kinases involved in leukemia cell survival and proliferation.

Limitations:
  • The study was limited to specific cohorts and may not represent all patient populations.
  • Further clinical trials are needed to confirm efficacy and safety in humans.
Conclusion:

NVP-BEP800 demonstrates promising anti-leukemic activity, warranting further investigation as a treatment option for T-ALL and B-ALL.

Original Source(s)

HSP90 inhibitor NVP-BEP800 affects stability of SRC kinases and growth of T-cell and B-cell acute lymphoblastic leukemias

  • by Rony Mshaik, John Simonet, Aleksandra Georgievski, Layla Jamal, Shaliha Bechoua, Paola Ballerini, Pierre-Simon Bellaye, Zandile Mlamla, Jean-Paul Pais de Barros, Audrey Geissler, Pierre-Jean Francin, François Girodon, Carmen Garrido, Ronan Quéré

  • March 18, 2021

Related Content

The 49th Annual Meeting of the European Society for Blood and Marrow Transplantation: Organising committee

  • November 9, 2023

Fertility preservation and subsequent reproductive outcomes in female pediatric patients with hematologic malignancies

Half a century of healing: celebrating the 50th anniversary of EBMT