Integrating multimodal prehabilitation into enhanced recovery after surgery programs (MPhERAS) for elderly patients: a systematic review and meta-analysis of randomized controlled trials and cohort studies - Summary - MDSpire

Integrating multimodal prehabilitation into enhanced recovery after surgery programs (MPhERAS) for elderly patients: a systematic review and meta-analysis of randomized controlled trials and cohort studies

  • By

  • A. Srinivasan

  • K. M. Yi

  • D. Sharma

  • S. K. Mantoo

  • December 27, 2025

  • 0 min

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Objective:

To evaluate the effectiveness of multimodal prehabilitation within ERAS specifically for elderly patients undergoing elective colorectal surgery.

Key Findings:
  • Six studies with low risk of bias and good quality were included, involving 547 patients aged 65-82 years, with an age range of 65-78 years in the intervention group and 66-82 years in the control group.
  • A statistically significant improvement was observed in the 6MWT (MD of 18.38 m; p = 0.0404).
  • No significant differences were found for LOS, postoperative complications, or QOL.
Interpretation:

While multimodal prehabilitation shows potential benefits in improving functional capacity, its limited impact on other clinical outcomes suggests further investigation is needed.

Limitations:
  • Limited clinical use of multimodal prehabilitation in ERAS for elderly patients may hinder broader application.
Conclusion:

Further research is needed to optimize specific aspects of multimodal prehabilitation interventions for selected patient populations undergoing elective colorectal surgery.

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