Stem-like CD8+ T cells preserve HBV-specific responses in HBV/HIV co-infection - Summary - MDSpire

Stem-like CD8+ T cells preserve HBV-specific responses in HBV/HIV co-infection

  • By

  • Anucha Preechanukul

  • Aljawharah Alrubayyi

  • Bo Sun

  • Edward Arbe-Barnes

  • Jonida Kokici

  • Frances Gorou

  • Sarun Prasitdumrong

  • Kelly A S da Costa

  • Natasha Fisher-Pearson

  • Noshin Hussain

  • Stephanie Kucykowicz

  • Indrajit Ghosh

  • Fiona Burns

  • Sabine Kinloch

  • Pedro Simoes

  • Sanjay Bhagani

  • Patrick T F Kennedy

  • Mala K Maini

  • Rachael Bashford-Rogers

  • Upkar S Gill

  • Dimitra Peppa

  • July 1, 2026

  • 0 min

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Objective:

To investigate the immune responses of individuals with HBV/HIV co-infection compared to those with HBV mono-infection in the context of current antiretroviral therapy.

Key Findings:
  • Individuals with HBV/HIV co-infection on antivirals exhibit a higher prevalence of precursor exhausted CD8+ T cells (Tpex) and more effective antiviral responses compared to those with HBV mono-infection.
  • There is a paradoxical increase in terminally exhausted CD8+ T cells in individuals with HBV mono-infection.
  • The study highlights the heterogeneous functional profiles of HBV-specific CD8+ T cells in the context of co-infection.
Interpretation:

The findings suggest that CD8+ T cell dynamics differ significantly between HBV mono-infection and HBV/HIV co-infection, indicating potential for tailored immunotherapies.

Limitations:
  • The study's sample size is relatively small, which may limit the generalizability of the findings.
  • Participants were recruited from specific centers, which may introduce selection bias.
Conclusion:

Understanding the immune responses in HBV/HIV co-infection could inform the development of immunotherapeutic strategies and clinical management practices.

Original Source(s)

Stem-like CD8+ T cells preserve HBV-specific responses in HBV/HIV co-infection

  • by Anucha Preechanukul, Aljawharah Alrubayyi, Bo Sun, Edward Arbe-Barnes, Jonida Kokici, Frances Gorou, Sarun Prasitdumrong, Kelly A S da Costa, Natasha Fisher-Pearson, Noshin Hussain, Stephanie Kucykowicz, Indrajit Ghosh, Fiona Burns, Sabine Kinloch, Pedro Simoes, Sanjay Bhagani, Patrick T F Kennedy, Mala K Maini, Rachael Bashford-Rogers, Upkar S Gill, Dimitra Peppa

  • July 1, 2026

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