Objective:

To investigate the role of lifestyle interventions, including physical activity, weight management, nutrition, sleep, and substance use, in enhancing quality of life and mitigating side effects for multiple myeloma patients, emphasizing their critical importance.

Key Findings:

• Multiple myeloma patients report a high symptom burden and low quality of life compared to other cancers, highlighting the need for targeted interventions.
• Only 6.8% of MM patients met physical activity guidelines during treatment, with even lower rates post-diagnosis, indicating a significant gap in adherence.
• Barriers to exercise include fatigue, pain, and lack of knowledge about safe exercise practices, which need to be addressed in future programs.
• 41.1% of MM patients expressed willingness to participate in disease-specific exercise programs, suggesting potential for engagement.

Interpretation:

There is a critical need to integrate lifestyle interventions into the care of multiple myeloma patients to improve their quality of life and functional status as they live longer with the disease, with specific implications for clinical practice.

Limitations:

• Few high-quality studies specifically address exercise interventions for multiple myeloma patients, limiting the evidence base.
• The older age demographic of MM patients may complicate the adoption of physical activity, necessitating tailored approaches.

Conclusion:

Incorporating lifestyle modifications, particularly physical activity, is essential for improving outcomes in multiple myeloma patients, but further research is needed to address barriers and enhance participation, particularly in older populations.