Early Neurodevelopmental Outcomes in Children With Congenital Heart Disease - Summary - MDSpire

Early Neurodevelopmental Outcomes in Children With Congenital Heart Disease

  • By

  • Mike Seed

  • Dawn Ilardi

  • Valerie Rofeberg

  • Cynthia Ortinau

  • Caren Goldberg

  • Garrett Reichle

  • Lauren Bush

  • Justin Elhoff

  • Amy Jo Lisanti

  • Jennifer Butcher

  • Caitlin Rollins

  • Andrew Van Bergen

  • Shabnam Peyvandi

  • Emily Bucholz

  • Stephanie Cox

  • Lyla Hampton

  • Jacqueline Sanz

  • Sonia Monteiro

  • Shruti Tewar

  • Kiona Allen

  • Caroline Lee

  • Kristi Glotzbach

  • Nneka Alexander

  • Laurel Bear

  • Corinne Anton

  • Renee Sananes

  • Linh Ly

  • Gina Boucher

  • Kelly Wolfe

  • Lindsay Edwards

  • Elizabeth Willen

  • Alexander Tan

  • Christina Ortega

  • Erica Sood

  • Anjali Sadhwani

  • Kari Crawford Plant

  • Lauren Quigley

  • Jessica Pliego

  • Elizabeth Valles

  • Abbey Hines

  • David Wypij

  • Thomas Miller

  • June 1, 2026

  • 0 min

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Objective:

To describe neurodevelopmental outcomes for infants and toddlers undergoing repair for congenital heart disease (CHD) and to understand the specific medical risk factors and social drivers associated with these outcomes.

Key Findings:
  • Neurodevelopmental delays affect up to half of children with CHD requiring surgical intervention.
  • Clinical risk factors include genetic diagnoses, prolonged hospitalization, and preterm birth.
  • Social drivers such as parental education and socioeconomic status are associated with neurodevelopmental outcomes.
  • Outcomes may vary by cardiac diagnosis, with improvements noted in patients with dextro-transposition of the great arteries (d-TGA) in recent years.
Interpretation:

The study aims to elucidate the multifactorial causes of neurodevelopmental differences in children with CHD, emphasizing the significant role of both medical and social factors.

Limitations:
  • The study is cross-sectional, limiting causal inferences.
  • Data may be affected by selection bias due to the waiver of consent, potentially skewing the results.
  • Not all patients underwent genetic testing, which may affect the assessment of genetic diagnoses.
Conclusion:

The findings highlight the complexity of neurodevelopmental outcomes in children with CHD and underscore the need for further research to understand the evolving associations between cardiac diagnoses and neurodevelopmental outcomes.

Original Source(s)

Early Neurodevelopmental Outcomes in Children With Congenital Heart Disease

  • by Mike Seed, Dawn Ilardi, Valerie Rofeberg, Cynthia Ortinau, Caren Goldberg, Garrett Reichle, Lauren Bush, Justin Elhoff, Amy Jo Lisanti, Jennifer Butcher, Caitlin Rollins, Andrew Van Bergen, Shabnam Peyvandi, Emily Bucholz, Stephanie Cox, Lyla Hampton, Jacqueline Sanz, Sonia Monteiro, Shruti Tewar, Kiona Allen, Caroline Lee, Kristi Glotzbach, Nneka Alexander, Laurel Bear, Corinne Anton, Renee Sananes, Linh Ly, Gina Boucher, Kelly Wolfe, Lindsay Edwards, Elizabeth Willen, Alexander Tan, Christina Ortega, Erica Sood, Anjali Sadhwani, Kari Crawford Plant, Lauren Quigley, Jessica Pliego, Elizabeth Valles, Abbey Hines, David Wypij, Thomas Miller

  • June 1, 2026

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