To propose and validate new pediatric EBMT criteria for diagnosing sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) in children post-hematopoietic stem cell transplantation (HSCT), emphasizing the need for prospective validation.
Key Findings:
The pEBMT criteria resulted in a higher incidence of VOD/SOS (15.9%) compared to Seattle (12.3%) and Baltimore (6.6%) criteria.
Diagnosis using pEBMT criteria occurred 2.5–3 days earlier.
75% of patients with VOD/SOS had refractory thrombocytopenia at diagnosis, highlighting its sensitivity.
61% of patients were anicteric at diagnosis, with most developing hyperbilirubinemia shortly after.
Interpretation:
The pEBMT criteria may improve early diagnosis and treatment of SOS/VOD in pediatric patients, potentially leading to better outcomes.
Limitations:
The data is primarily retrospective and requires prospective validation.
Baseline ultrasound assessments were not standard in previous studies, complicating the evaluation of TRT and its implications.
Conclusion:
The pEBMT criteria show promise in enhancing the diagnosis and management of SOS/VOD in children, warranting further prospective studies to confirm their efficacy and address the challenges identified.
