To document the diagnosis and treatment of a 14-year-old patient with Proteus syndrome who developed severe soft tissue infection and to enhance awareness of the clinical presentations and management strategies for Proteus syndrome.
Key Findings:
The patient developed a severe soft tissue infection secondary to lower limb deformity.
Initial treatment with cefotiam was ineffective due to liver damage and bacterial resistance.
The clinical pharmacist optimized the treatment regimen, leading to significant improvement in the patient's condition and highlighting the importance of collaborative care.
Interpretation:
The case highlights the importance of a coordinated healthcare approach and individualized treatment in managing complications associated with Proteus syndrome, emphasizing the role of clinical pharmacists.
Limitations:
The rarity of Proteus syndrome limits the generalizability of findings and highlights the need for more comprehensive studies.
Limited reports on targeted therapeutic agents for Proteus syndrome restrict the understanding of effective treatments.
Conclusion:
The case emphasizes the need for enhanced clinical management strategies for patients with Proteus syndrome to improve outcomes, particularly through individualized treatment and coordinated care.
A posthoc analysis of a phase 2b trial found favorable changes in DNA methylation–based aging biomarkers among patients with human immunodeficiency virus–associated lipohypertrophy.
