Objective:

To systematically compare the prognostic value of nine inflammation-derived hematological indices in predicting 28-day mortality in sepsis patients.

Approach:

Key Findings:

• Inthedevelopmentcohortof26,512patients,allnineindicesweresignificantlyassociatedwith28-daymortality.Monocyte-to-lymphocyteratio,neutrophil-to-plateletratio,neutrophil-to-lymphocyteratio,andsystemicinflammationresponseindexhadlargereffectestimates.Neutrophil-to-lymphocyteratioshowedthehighestareaunderthecurveforunadjusteddiscrimination.Intheexternalvalidationcohortof850patients,noneoftheindicesremainedsignificantlyassociatedwith28-daymortalityafterfulladjustment.

Interpretation:

Inflammation-derived hematological indices showed non-linear risk patterns in the development cohort but had limited standalone discriminatory ability in the external validation cohort.

Limitations:

• Theexternalvalidationdidnotconfirmtheassociationsfoundinthedevelopmentcohort,andtheindicesmaynotserveasindependentmortalitypredictiontools.

Conclusion:

These indices may serve as supplementary markers alongside conventional severity scores rather than independent predictors of mortality.

Attribution Notice

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.