Cardiometabolic index and modified cardiometabolic index are associated with early neurological deterioration in patients with acute ischemic stroke - Summary - MDSpire

Cardiometabolic index and modified cardiometabolic index are associated with early neurological deterioration in patients with acute ischemic stroke

  • By

  • Li Xu

  • Fan Liu

  • Xiaoran Zhang

  • Zhe Xie

  • Wenwei Zou

  • Mengchao Wang

  • Zhongwen Zhi

  • Yufeng Liu

  • Liandong Zhao

  • May 4, 2026

  • 0 min

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Objective:

To assess the association of cardiometabolic index (CMI) and modified cardiometabolic index (MCMI) with early neurological decline (END) in patients with acute ischemic stroke (AIS).

Key Findings:
  • 123 patients experienced END during hospitalization.
  • CMI and MCMI levels were significantly higher in the END group compared to the non-END group (p < 0.001).
  • Both CMI and MCMI were independent risk factors for END (all p < 0.05).
  • Nonlinear relationships were observed between CMI, MCMI, and END, with specific p-values indicating significance.
Interpretation:

Elevated CMI and MCMI upon admission are associated with an increased risk of early neurological decline in AIS patients, suggesting their potential use in early risk stratification and clinical decision-making.

Limitations:
  • Retrospective design may introduce selection bias.
  • Single-center study limits generalizability.
  • Potential confounding factors were not controlled for in the analysis.
Conclusion:

CMI and MCMI are valuable indicators for predicting early neurological decline in AIS patients, which may aid in clinical decision-making.

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