To analyze peripheral blood cytotoxic markers in hepatobiliary surgical patients and determine the influence of age and disease category on cytotoxic marker expression.
Key Findings:
NK cells exhibited higher cytotoxic marker expression than T-cell subsets.
No significant differences in cytotoxic marker expression across disease groups, even after age adjustment.
All markers positively correlated with age, indicating the impact of immunosenescence.
In acute pancreatitis, CD8+Perforin+ levels were higher in severe cases with moderate discriminative performance.
CD8+Granzyme B+ correlated with bilirubin, albumin, AST, and lymphocyte count.
Interpretation:
Remove unsupported conclusions and interpretations.
Limitations:
Single-center study may limit generalizability.
Retrospective design may introduce selection bias.
Conclusion:
Remove unsupported implications and ensure it reflects only the findings stated in the source.
